Chronic infections over 600 million of people worldwide are due to Hepatitis B and C virus favouring liver injury such as steatosis and fibrosis that can lead to cirrhosis and hepatocellular carcinoma ahead liver destruction. New studies have shown that cyclophilin D can affect the virus replication cycle. Fabien Zoulim has been simply involved in the OPeRa project.
Research point of view:
Pr. Fabien Zoulim and his team have developed a new hepatocyte cell line model to study mechanisms and virus multiplication according to several factors.
This model is used to analyse and study the cyclophylin D (Cyp D used by the workpackage number 4 dedicated to the cardioprotection research) on the VHC replication.
Research point of care:
If the Cyclophylin D role as inhibitor of the VHC and VHB replication is confirmed, then new clinical trials will be designed and realized.
Interview et Articles sur Fabien Zoulim :
- Hepatite B and pathogenesis at CRCL